1,1'-Carbonyldiimidazole → HCID 178466022, compound

Participants

Reaction Steps

7-Ethoxy-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (1.9 g) and N,N-carbonyldiimidazole (2 g) in dimethylformamide (50 ml) were stirred and heated at 100° for 4 hours. 5-Amino-1H-tetrazole (2.1 g) was added and the mixture stirred and heated at 100° for 30 minutes, and cooled. The solid was collected and dissolved in hot (60°) dilute sodium hydroxide and the solution was neutralised (pH 7) with dilute hydrochloric acid. The solid was collected, washed with water and dried, m.p. above 319° (d), (75%).

Provenance & Evidence