Formic Acid → HCID 21435004, compound

HRID 2398246Notes

Reaction equation

HRID 2398246 reaction equation
[CH:1]([OH:3])=[O:2].C(OC(=O)C)(=O)C.[CH2:11]([O:13][C:14]1[N:23]=[C:22]2[C:17]([C:18](=[O:30])[C:19]([C:27]([OH:29])=[O:28])=[CH:20][N:21]2[CH:24](O)[CH3:25])=[CH:16][CH:15]=1)[CH3:12]>N1C=CC=CC=1>[CH2:11]([O:13][C:14]1[N:23]=[C:22]2[C:17]([C:18](=[O:30])[C:19]([C:27]([OH:29])=[O:28])=[CH:20][N:21]2[CH2:24][CH2:25][O:2][CH:1]=[O:3])=[CH:16][CH:15]=1)[CH3:12]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 21435033HCID 21435033, compound

Product 1

HCID 21435004HCID 21435004, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Formic acid (1 ml) was added to acetic anhydride (2 ml) which was cooled to 0°. The mixture was warmed to 50° for 15 minutes, cooled to 0° and added to a suspension of 7-ethoxy-1,4-dihydro-1-hydroxyethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (0.78 g) in dry pyridine (10 ml). The mixture was stirred at 0° for 45 minutes and then for 1 hour at room temperature. The solid was collected and washed with water and dried, m.p. 208.5°-210° (d). (71%).

Workup

  1. temperaturewas cooled to 0°
  2. temperatureThe mixture was warmed to 50° for 15 minutes
  3. temperaturecooled to 0°
  4. waitfor 1 hour at room temperature
  5. customThe solid was collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-07dbccfed85a4da589f3e1d2cd10f373
Source dataset
uspto-grants-1977_05
Patent number
US04024255

Reaction notes

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