HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 7-Chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178524789 | HCID 178524789 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | HCID 13495954 | — |
Reaction Steps
1,4-Dihydro-7-hydroxy-4-oxo-1,8-naphthyridine-3-carboxylic acid (10 g) and phosphoryl chloride (20 ml) were stirred and heated at 100° for 2.5 hours. The mixture was cooled and poured into iced water (800 ml). The solid was filtered off and crystallized from dimethylformamide, m.p. 271°-273° (87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04024255 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-299fc37f3d494a799d82205ac5b159b9 |
| Source note | uspto-grants-1977_05 |