HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Bis(methylthio)-2-nitroethylene → 1-Nitro-2-methylthio-2-[2-(2-pyridylmethylthio)ethylamino]ethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Bis(methylthio)-2-nitroethylene | HCID 83623 | — |
| Reactant | 2-((2-Aminoethyl)thiomethyl)pyridine | HCID 12889401 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Nitro-2-methylthio-2-[2-(2-pyridylmethylthio)ethylamino]ethylene | HCID 70570329 | 29.4% |
Reaction Steps
A solution of 2-[(2-aminoethyl)thiomethyl]pyridine (5.0 g) and 1-nitro-2,2-bis-methylthioethylene (5.28 g) in ethanol was heated under reflux for 3 hours. Concentration and chromatographic purification of the product on a column of silica gel with elution by isopropyl alcohol-ethylacetate (1:5) gave 1-nitro-2-methylthio-2-[2-(2-pyridylmethylthio)-ethylamino]ethylene (2.49 g), m.p. 95.5°-96.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04024260 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-5051ab4afd764c05b26dd633a2e1f0c5 |
| Source note | uspto-grants-1977_05 |