HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-Methyl-7-(3-nitrophenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid 6-methyl ester 8-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 3-Nitrobenzylideneacetoacetic acid methyl ester | HCID 53443010 | — |
| Reactant | Ethyl (pyrrolidin-2-ylidene)acetate | HCID 68118984 | — |
| Product | 5-Methyl-7-(3-nitrophenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid 6-methyl ester 8-ethyl ester | HCID 54433068 | 73% |
Reaction Steps
Upon boiling a solution of 8.3 g of 3-nitrobenzylideneacetoacetic acid methyl ester and 5.6 g of 2-carbethoxymethylidenepyrrolidine in 50 ml of glacial acetic acid for 8 hours, 5-methyl-7-(3-nitrophenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid 6-methyl ester 8-ethyl ester of melting point 120° (ethanol) is obtained. Yield: 73% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04024261 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-e12e11370eba459b9235c822ed9698c0 |
| Source note | uspto-grants-1977_05 |