HCID 54494287, compound → HCID 54354617, compound

Participants

Reaction Steps

A solution of 114 g of 1-ethoxycarbonyl-3-benzyl-4-piperidylidene-acetic acid ethyl ester in 120 cc of ethyl acetate is hydrogenated in the presence of 15 g of 10% palladium on charcoal at 11 atmospheres and at a temperature of 50° for 18 hours. After removing the catalyst, the solvent is evaporated at reduced pressure. The 1-ethoxycarbonyl-3-benzyl-4-piperidine-acetic acid ethyl ester (mixture of isomers) obtained as residue, is used for the next reaction step without purification.

Provenance & Evidence