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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239831Generated: October 26, 2026

4-t-Butylbenzenesulfonyl chloride → 4-tert-Butyl-N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]benzenesulfonamide

https://huagongshe.com/reaction/239831

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-t-Butylbenzenesulfonyl chlorideHCID 139882—
Reactant4-Chloro-2-(4-fluorobenzoyl)anilineHCID 10955955—
Product4-tert-Butyl-N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]benzenesulfonamideHCID 11305378—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 125 mg of (2-Amino-5-chloro-phenyl)-(4-fluoro-phenyl)-methanone and 116 mg of 4-tert-butyl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.21 (s, 9H), 7.09 (t, 2H, J=8.8 Hz), 7.29 (m, 3H), 7.43-7.50 (m, 3H), 7.59 (m, 2H), 7.77 (d, 1H, J=8.8 Hz), 9.72 (s, 1H). MS: m/z 446.0 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08642808B2
Source datasetuspto-grants-2014_02
ORD IDord-b67d4fb1bd7d4f3690546e016f41dde3
Source noteuspto-grants-2014_02