HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → HCID 178486120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178486120 | HCID 178486120 | — |
Reaction Steps
(i) Potassium carbonate (7.75 g.) was added to a solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (14.6 g.) in water (120 ml.). The solution was stirred at room temperature for 15 minutes and methyl isothiocyanate (5.15 g.) was added. After heating under reflux for 30 minutes, the solution was slowly cooled to 5°. The product (13.1 g.) was collected and recrystallised from water to give N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea, m.p. 150°-152°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04024271 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-93e9f969be954c81b283bb16b1e07ecc |
| Source note | uspto-grants-1977_05 |