N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]thiourea → HCID 57218170, compound

HRID 2398418Notes

Reaction equation

HRID 2398418 reaction equation
[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][NH:8][CH2:9][C:10]1[N:11]=[CH:12][O:13][C:14]=1[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=S.[N:22]#[C:23][NH2:24].[Pb]>>[CH2:15]([C:14]1[O:13][CH:12]=[N:11][C:10]=1[CH2:9][NH:8][CH2:7][CH2:6][NH:5][C:3]([NH:24][C:23]#[N:22])=[N:2][CH3:1])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 20557842N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]thioureaHCID 22262466CH2N2Pb

Product 1

HCID 57218170HCID 57218170, compound

Procedure

Reacting ethylenediamine with 5-benzyl-4-chloromethyloxazole by the procedure of Example 34, then reacting the resulting N-(5-benzyl-4-oxazolylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) and chromatographing gives N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]thiourea. Reacting this thiourea with lead cyanamide by the procedure of Example 3(b) gives N-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]-N'-cyano-N"-methylguanidine.

Sources & evidence

ORD record
ord-8acd7efb0e9140229b5c892ad8e7133f
Source dataset
uspto-grants-1977_05
Patent number
US04024271

Reaction notes

Loading…