HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylenediamine → N-cyano-N'-ethyl-N"-[2-((4-methyl-5-oxazolyl)methylamino)ethyl]guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | Ethyl isothiocyanate | HCID 10966 | — |
| Reactant | 5-(Chloromethyl)-4-methyl-1,3-oxazole | HCID 205485 | — |
| Reactant | N-(4-methyl-5-oxazolylmethyl)ethylenediamine | HCID 14009880 | — |
| Product | N-cyano-N'-ethyl-N"-[2-((4-methyl-5-oxazolyl)methylamino)ethyl]guanidine | HCID 57257796 | — |
Reaction Steps
Reaction of 5-chloromethyl-4-methyloxazole with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(4-methyl-5-oxazolylmethyl)ethylenediamine with ethyl isothiocyanate by the procedure of Example 3 (b) gives, after purifying by column chromatography, N-ethyl-N'-[2-(4-methyl-5-oxazolylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Example 3(b) to give N-cyano-N'-ethyl-N"-[2-((4-methyl-5-oxazolyl)methylamino)ethyl]guanidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04024271 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-45aa9778f2114490b6ef878c9c1eac74 |
| Source note | uspto-grants-1977_05 |