2-[(2-Aminoethyl)thiomethyl]benzimidazole → HCID 178512222, compound

HRID 2398425Notes

Reaction equation

HRID 2398425 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[NH:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.CS[C:17](=[NH:22])[NH:18][N+:19]([O-:21])=[O:20]>>[N:10]1[C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[NH:7][C:6]=1[CH2:5][S:4][CH2:3][CH2:2][NH:1][C:17]([NH:18][N+:19]([O-:21])=[O:20])=[NH:22]

Participants

3

Reactant 2

HCID 129234202-[(2-Aminoethyl)thiomethyl]benzimidazoleHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 178512222HCID 178512222, compound

Procedure

Reacting 2-[(2-aminoethyl)thiomethyl]benzimidazole with S-methyl-N-nitroisothiourea by the procedure of Example 2(ii) gives N-[2-(2-benzimidazolylmethylthio)ethyl]-N'-nitroguanidine. Treatment with hydrochloric acid gives the hydrochloride salt.

Sources & evidence

ORD record
ord-c378620f833f446a9e15dc291cc597b6
Source dataset
uspto-grants-1977_05
Patent number
US04024271

Reaction notes

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