5-Chloro-2-phenylbenzofuran → 5-Chloro-3-[4-(2-diethylaminoethoxy)benzoyl]-2-phenylbenzofuran

HRID 2398451Notes

Reaction equation

HRID 2398451 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:7][C:6]=2[CH:16]=1.Cl.[CH2:18]([N:20]([CH2:33][CH3:34])[CH2:21][CH2:22][O:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=1)[CH3:19]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[C:7]([C:28](=[O:29])[C:27]3[CH:26]=[CH:25][C:24]([O:23][CH2:22][CH2:21][N:20]([CH2:33][CH3:34])[CH2:18][CH3:19])=[CH:32][CH:31]=3)[C:6]=2[CH:16]=1

Participants

3

Reactant 2

HCID 6150425-Chloro-2-phenylbenzofuranHCID 161118754-(2-Diethylaminoethoxy)benzoyl chloride hydrochloride

Product 1

HCID 214352795-Chloro-3-[4-(2-diethylaminoethoxy)benzoyl]-2-phenylbenzofuran

Procedure

Acylation of 5-chloro-2-phenylbenzofuran with 4-(2-diethylaminoethoxy)benzoyl chloride hydrochloride as described in the procedure of Example 6 gives the title compound which is converted to the corresponding hydrochloride salt as described in the procedure of Example 1, m.p. 197°-199° (ethyl acetate).

Sources & evidence

ORD record
ord-e596c187ab654e8fa89ebfcdb2cea89f
Source dataset
uspto-grants-1977_05
Patent number
US04024273

Reaction notes

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