HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3'-(Trifluoromethyl)acetophenone | HCID 67682 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one | HCID 2778386 | — |
Reaction Steps
To a solution of 24.8 g. (0.127 mol.) of m-trifluoromethylacetophenone in 20 ml. of anhydrous ether is added with cooling and stirring 0.15 g. of anhydrous aluminum chloride and 20.2 g. (0.127 mol.) of bromine. The reaction mixture is concentrated and the residue is distilled to give α-bromo-m-trifluoromethylacetophenone, b.p. 135°-140° (20 mm.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04024273 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-5d422b5ce7ac4fb89fae7dc40f3ede38 |
| Source note | uspto-grants-1977_05 |