Sodium Methoxide → HCID 68121576, compound

Participants

Reaction Steps

To a solution of Compound VII (5 g, 16.4 mmoles) in absolute methanol (30 ml) was added M sodium methoxide (0.5 ml), and the mixture was kept for 12 hours at 25° C, at which point, t.l.c. (2:3 benzene-acetone) indicated that saponification was complete. The solution was passed through a small bed (250 × 20 mm) of silica gel in a column, and the effluent was evaporated in vacuo to give Compound VIII as a syrup, yield 3.2 g (97%); this was subjected, without delay, to the hydrogenation step of Example 8.

Provenance & Evidence