HCID 178468101, compound → HCID 178468102, compound

HRID 2398513Notes

Reaction equation

HRID 2398513 reaction equation
[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:18]([NH:20][C@H:21]([C:32]([NH:34][C@H:35]([C:38]([NH:40][C@H:41]([C:50]([NH:52][C@@H:53]([C:63]([NH:65][C@H:66]([C:71]([NH:73][C@H:74]([C:82]([N:84]1[CH2:93][CH2:92][CH2:91][C@H:85]1[C:86]([NH:88][CH2:89][CH3:90])=[O:87])=[O:83])[CH2:75][CH2:76][CH2:77][NH:78][C:79](=[NH:81])[NH2:80])=[O:72])[CH2:67][CH:68]([CH3:70])[CH3:69])=[O:64])[CH2:54][CH2:55][C:56](=[O:62])[O:57]C(C)(C)C)=[O:51])[CH2:42][C:43]1[CH:48]=[CH:47][C:46]([OH:49])=[CH:45][CH:44]=1)=[O:39])[CH2:36][OH:37])=[O:33])[CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)=[O:19])[CH2:12][C:13]1[N:17]=[CH:16][NH:15][CH:14]=1)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[OH:6].[CH3:94][C:95]([CH2:97][C:98]([OH:100])=[O:99])=[O:96]>O>[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:18]([NH:20][C@H:21]([C:32]([NH:34][C@H:35]([C:38]([NH:40][C@H:41]([C:50]([NH:52][C@@H:53]([C:63]([NH:65][C@H:66]([C:71]([NH:73][C@H:74]([C:82]([N:84]1[CH2:93][CH2:92][CH2:91][C@H:85]1[C:86]([NH:88][CH2:89][CH3:90])=[O:87])=[O:83])[CH2:75][CH2:76][CH2:77][NH:78][C:79](=[NH:80])[NH2:81])=[O:72])[CH2:67][CH:68]([CH3:70])[CH3:69])=[O:64])[CH2:54][CH2:55][C:56](=[O:57])[OH:62])=[O:51])[CH2:42][C:43]1[CH:48]=[CH:47][C:46]([OH:49])=[CH:45][CH:44]=1)=[O:39])[CH2:36][OH:37])=[O:33])[CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)=[O:19])[CH2:12][C:13]1[N:17]=[CH:16][NH:15][CH:14]=1)=[O:9])[CH2:3][CH2:4][C:5](=[O:6])[OH:7].[CH3:94][C:95]([CH2:97][C:98]([OH:100])=[O:99])=[O:96]

Participants

3

Reactant 1

HCID 178468101HCID 178468101, compound

Product 1

HCID 178468102HCID 178468102, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

190 mg of Glu-His-Trp-Ser-Tyr-D-Glu(OBut)-Leu-Arg-Pro-NH-C2H5 -diacetate were reacted and purified in analogy to Example 1 g). Yield: 148.9 mg. The content of peptide base was 85% as per UV-spectrum. [-α]D22 = -47.8° (c=1, in H2O)

Sources & evidence

ORD record
ord-5779e8ed0064459ca8b9df14b303c7fe
Source dataset
uspto-grants-1977_05
Patent number
US04024248

Reaction notes

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