p-Anisoyl chloride → HCID 21433227, compound

HRID 2398535Notes

Reaction equation

HRID 2398535 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([Br:12])=[CH:4][C:3]=1[S:13]([NH2:16])(=[O:15])=[O:14].[C:17](Cl)(=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1>>[C:17]([NH:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:11])[F:10])[C:5]([Br:12])=[CH:4][C:3]=1[S:13]([NH2:16])(=[O:14])=[O:15])(=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 21433224HCID 21433224, compound2×

Product 1

HCID 21433227HCID 21433227, compound

Procedure

2-Amino-4-trifluoromethyl-5-bromo-benzenesulfonamide (formula (V): R2 = Br) is first prepared according to the above-described technique. M.p.= 202° C. The 2-amino-4-trifluoromethyl-5-bromobenzenesulfonamide (9.60 g) is then reacted, as in Example 2A, with p-anisic acid chloride (6.8 g), to give 12.2 g 2-p-anisoylamino-4-trifluoromethyl-5-bromo-benzenesulfonamide, M.p.= 321° C.

Sources & evidence

ORD record
ord-9cb1bd12b84343c8a2309c37984764f9
Source dataset
uspto-grants-1977_05
Patent number
US04025508

Reaction notes

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