HCID 54283452, compound → HCID 53663414, compound

Participants

Reaction Steps

The mixture of 3.0 g of N-(4-nitro-2-methylmercaptomethylphenyl)-4-chlorophthalimide, 1.5 g of Raney nickel and 250 ml of ethyl acetate is hydrogenated at room temperature and atmospheric pressure until the hydrogen uptake ceases. It is filtered, the filtrate evaporated and the residue recrystallized from benzene, to yield the N-(4-amino-2-methylmercaptomethylphenyl)-4-chlorophthalimide melting at 134°-137°. Analogously the N-(4-amino-2-methylsulfonylmethylphenyl)-4-chlorophthalimide is prepared, m.p. 253°-257° (acetonitrile); as well as the N-(4-amino-2-hydroxymethylphenyl)-4-chlorophthalimide, m.p. 228°-230° (ethyl acetatediethyl ether).

Provenance & Evidence