Hydrogen Peroxide → Cyclohexylurea

Participants

Reaction Steps

5 Grams N-[4-(β-<N'-methyl-N'-pyridyl-ureido>-ethyl)-benzenesulfonyl]-N'-cyclohexyl-thio-urea (prepared by reaction of 4-(β-<N'-methyl-N'-2-pyridyl-ureido>-ethyl)-benzenesulfonamide and cyclohexylisothiocyanate in an acetonic solution in the presence of potassium carbonate, melting point 143°-145° C. from methanol) were dissolved in 50 ml of 1N sodium hydroxide solution. 5 Milliliters of 30% H2O2 were added and the mixture was heated for 15 minutes on the steam bath. After cooling the solution was acidified. The precipitate was suction-filtered and recrystallized from ethanol/dimethylformamide. The N'-[4-(β-<N'-methyl-N'-2-pyridyl-ureido>-ethyl)-benzenesulfonyl]-N'-cyclohexyl-urea obtained melted at 167°-169° C.

Provenance & Evidence