HRID239861

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68443743

未命名化合物

结构：CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2Cl)cc1)C(F)(F)F)C(=O)O

HCID68444063

未命名化合物

PRODUCTS

生成物

结构：CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2Cl)cc1)C(F)(F)F)C(=O)NC(C#N)Cc1ccc(C#N)cc1F

HCID42633147

未命名化合物

PROCEDURE

实验过程

(S)-2-[(S)-1-(2′-Chloro-4′-methanesulfonyl-biphenyl-4-yl)-2,2,2-trifluoro-ethylamino]-4-fluoro-4-methyl-pentanoic acid [1-cyano-2-(4-cyano-2-fluoro-phenyl)-ethyl]-amide was prepared from N-{(1S)-1-[2′-chloro-4′-(methylsulfonyl)biphenyl-4-yl]-2,2,2-trifluoroethyl}-4-fluoro-L-leucine and 4-[(2S)-(2-amino-2-cyanoethyl)]-3-fluorobenzonitrile using procedure described in Example 6.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-156c83722fb242b8847d1519f2f4bc77
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08642799B2
来源说明: uspto-grants-2014_02

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([C@H:18]([NH:23][C@H:24]([C:30](O)=[O:31])[CH2:25][C:26]([F:29])([CH3:28])[CH3:27])[C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=1.[NH2:33][C@H:34]([C:45]#[N:46])[CH2:35][C:36]1[CH:43]=[CH:42][C:39]([C:40]#[N:41])=[CH:38][C:37]=1[F:44]>>[C:45]([CH:34]([NH:33][C:30](=[O:31])[C@@H:24]([NH:23][C@@H:18]([C:15]1[CH:16]=[CH:17][C:12]([C:3]2[CH:4]=[CH:5][C:6]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:7][C:2]=2[Cl:1])=[CH:13][CH:14]=1)[C:19]([F:22])([F:21])[F:20])[CH2:25][C:26]([F:29])([CH3:27])[CH3:28])[CH2:35][C:36]1[CH:43]=[CH:42][C:39]([C:40]#[N:41])=[CH:38][C:37]=1[F:44])#[N:46]