Phosphorus pentachloride → HCID 178479351, compound

HRID 2398626Notes

Reaction equation

HRID 2398626 reaction equation
[ClH:1].[C:2]([NH:10][CH2:11][C:12]([OH:14])=O)(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:16]>C(Cl)Cl>[ClH:16].[C:2]([NH:10][CH2:11][C:12]([Cl:1])=[O:14])(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 178479352HCID 178479352, compound

Product 1

HCID 178479351HCID 178479351, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To benzimidoylaminoacetic acid hydrochloride (2.2 g., 10 mmoles) in 40 ml. of dry methylene chloride is added 2.5 g. (12 mmoles) of phosphorous pentachloride, and the reaction mixture allowed to stir overnight at room temperature. The product is filtered, washed successively with methylene chloride (50 ml. ), chloroform 2× 75 ml.) and hexane (50 ml.) and dried in vacuo, 2.5 g. (99% yield).

Workup

  1. filtrationThe product is filtered
  2. washwashed successively with methylene chloride (50 ml. ), chloroform 2× 75 ml
  3. dry with material) and hexane (50 ml.) and dried in vacuo, 2.5 g

Sources & evidence

ORD record
ord-8472ed6ac61a4e67b131e5ed0c83f3cf
Source dataset
uspto-grants-1977_05
Patent number
US04025506

Reaction notes

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