HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2398641Generated: October 30, 2026
Phenol → Ethyl 2-phenoxy-5-thiazolecarboxylate
https://huagongshe.com/reaction/2398641
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 2-bromothiazole-5-carboxylate | HCID 3614103 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-phenoxy-5-thiazolecarboxylate | HCID 13106142 | 96.6% |
Reaction Steps
Ethyl 2-bromo-5-thiazolecarboxylate(10 g), phenol (4.38 g) and potassium carbonate powder (11.7 g) are suspended in dimethylformamide (50 ml) and the suspension is stirred for 3 hours at 80° C. The reaction mixture is treated in the same manner as in Example 1 to give ethyl 2-phenoxy-5-thiazolecarboxylate (10.2 g) boiling at 127°-128° C. at 1 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04025528 |
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| Source dataset | uspto-grants-1977_05 |
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| ORD ID | ord-5735cdddb8db458baf5f60070f5733c1 |
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| Source note | uspto-grants-1977_05 |
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