HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → Ethyl 2-phenylthio-4-methyl-5-thiazolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate | HCID 2824057 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-phenylthio-4-methyl-5-thiazolecarboxylate | HCID 20364661 | 98.5% |
Reaction Steps
A suspension of ethyl 2-bromo-4-methyl-5-thiazole-carboxylate (22 g), thiophenol (10.75 g) and potassium carbonate powder (24.3 g) in dimethylformamide (100 ml) is stirred. for 4 hours at 80° C. The reaction mixture is treated in the same manner as in Example 1 to give ethyl 2-phenylthio-4-methyl-5-thiazolecarboxylate (24.2 g) boiling at 160°-161° C. at 1 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04025528 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-dff8a5523de54a40b112e917170e4369 |
| Source note | uspto-grants-1977_05 |