Bromoform → HCID 21433718, compound

Participants

Reaction Steps

Cyclotetradecene (40 g), bromoform (75.9 g), 50% aqueous sodium hydroxide solution (300 ml), dichloromethane (20 ml), tri-sec-octyl methylammonium chloride (1 drop) and 1 drop of a long-chain alcohol ethoxylate of the structure [C14-15 ] [OC2 ]11 --OH (Dobanol 45 + 11 EO, Shell Chemicals) were stirred together at 40° C. for 7 hours. The organic layer was separated and the volatile organic components removed under reduced pressure. The residue was dissolved in pentane and the solution was stirred with active charcoal (Norit). The solution was filtered and the pentane removed under reduced pressure to give the required product in almost 100% yield.

Provenance & Evidence