HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-dimethylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Chloro-7-(trifluoromethyl)quinoline | HCID 67668 | — |
| Reactant | 4-Amino-N,N-dimethylbenzamide | HCID 235527 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-dimethylbenzamide | HCID 21433867 | — |
Reaction Steps
A mixture of 0.1 mole of N,N-dimethyl-p-aminobenzamide, 0.1 mole of 4-chloro-7-trifluoromethylquinoline, 8 ml. of concentrated hydrochloric acid and 500 ml. of absolute ethanol is heated at reflux for 19 hours, after which 100 ml. of 2.5N sodium hydroxide is added. The mixture is cooled and filtered and the filter cake is recrystallized from methanol. There is thus obtained p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-dimethylbenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04025629 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-571c6d3402fc4c39a9d1a70b7c14419a |
| Source note | uspto-grants-1977_05 |