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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2398746Generated: October 31, 2026

Acetic Acid → 5-Benzoxazoleacetic acid, 2-phenyl-

https://huagongshe.com/reaction/2398746

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantMethaneHCID 297—
ReactantHCID 21434017HCID 21434017—
CatalystPalladiumHCID 23938—
Product5-Benzoxazoleacetic acid, 2-phenyl-HCID 37928—

Reaction Steps

A solution of α-hydroxy-2-phenyl-5-benzoxazolyl-acetonitrile (2 g.) in acetic acid (30 ml.) containing palladium or charcoal was hydrogenated for 4 hours. The catalyst was filtered off and the solution was evaporated to dryness. The residue was recrystallised to give pure 2-phenyl-5-benzoxazolylacetic acid m.p. 175° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04025636
Source datasetuspto-grants-1977_05
ORD IDord-ace5b03aa5ab4d35906bed6526170fa3
Source noteuspto-grants-1977_05