反应详情

A solution of methyl α-bromo-2-p-chlorophenyl-5-benzoxazolylacetate (3 g.) in dioxan (30 ml.) was treated with aqueous 2N sodium hydroxide solution. The mixture was acidified and crude α-bromo-2-p-chlorophenyl-5-benzoxazolylacetic acid was filtered off. This solid was dissolved in ethanol (30 ml.) and palladium on charcoal added. The solution was hydrogenated for 3 hours. The catalyst was removed and the solution was evaporated to dryness. The residue was crystallised to give 2-p-chlorophenyl-5-benzoxazolylacetic acid, m.p. 241°-242° C.

1. filtrationcrude α-bromo-2-p-chlorophenyl-5-benzoxazolylacetic acid was filtered off
2. dissolutionThis solid was dissolved in ethanol (30 ml.)
3. additionpalladium on charcoal added
4. customThe catalyst was removed
5. customthe solution was evaporated to dryness
6. customThe residue was crystallised