Dicyclohexylcarbodiimide → HCID 21433895, compound

HRID 2398870Notes

Reaction equation

HRID 2398870 reaction equation
[CH3:1][C:2]1([CH3:30])[C:25]2[CH2:26][CH2:27][NH:28][CH2:29][C:24]=2[C:5]2[C:6]([OH:23])=[CH:7][C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[C:17]([F:22])[CH:16]=3)=[CH:9][C:4]=2[O:3]1.[ClH:31].[O:32]1[CH2:37][CH2:36][N:35]([CH2:38][CH2:39][CH2:40][C:41]([OH:43])=O)[CH2:34][CH2:33]1.[CH:44]1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[ClH:31].[CH3:1][C:2]1([CH3:30])[C:25]2[CH2:26][CH2:27][N:28]([CH3:44])[CH2:29][C:24]=2[C:5]2[C:6]([O:23][C:41](=[O:43])[CH2:40][CH2:39][CH2:38][N:35]3[CH2:36][CH2:37][O:32][CH2:33][CH2:34]3)=[CH:7][C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[C:17]([F:22])[CH:16]=3)=[CH:9][C:4]=2[O:3]1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 127337464-Morpholin-4-Yl-Butyric Acid HydrochlorideHCID 20361123HCID 20361123, compound

Product 1

HCID 21433895HCID 21433895, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5,5-Dimethyl-10-hydroxy-8-(3,4-difluorophenyl-n-pentyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine, γ-morpholino-butyric acid hydrochloride and dicyclohexylcarbodiimide are combined in equimolar amounts in methylene chloride and reacted as in Example 7 to give the desired product.

Workup

  1. customreacted as in Example 7

Sources & evidence

ORD record
ord-20c275e7d4d34878b646b0576a1b1b40
Source dataset
uspto-grants-1977_05
Patent number
US04025630

Reaction notes

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