Dicyclohexylcarbodiimide → HCID 70623121, compound

HRID 2398872Notes

Reaction equation

HRID 2398872 reaction equation
[CH3:1][C:2]1([CH3:37])[C:24]2[CH2:25][CH2:26][N:27]([CH2:29][CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:28][C:23]=2[C:5]2[C:6]([OH:22])=[CH:7][C:8]([C:10]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)([CH3:14])[CH2:11][CH2:12][CH3:13])=[CH:9][C:4]=2[O:3]1.Cl.[N:39]1([CH2:44][CH2:45][CH2:46][C:47](O)=[O:48])[CH2:43][CH2:42][CH2:41][CH2:40]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:21].[CH3:37][C:2]1([CH3:1])[C:24]2[CH2:25][CH2:26][N:27]([CH2:29][CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:28][C:23]=2[C:5]2[C:6]([O:22][C:47](=[O:48])[CH2:46][CH2:45][CH2:44][N:39]3[CH2:43][CH2:42][CH2:41][CH2:40]3)=[CH:7][C:8]([C:10]([C:15]3[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=3)([CH3:14])[CH2:11][CH2:12][CH3:13])=[CH:9][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 148556824-(Pyrrolidin-1-yl)butanoic acid hydrochlorideHCID 54187595HCID 54187595, compound

Product 1

HCID 70623121HCID 70623121, compound

Procedure

5,5-Dimethyl-10-hydroxy-2-phenethyl-8-(4-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano [3,4-d]pyridine, γ-pyrrolidino-butyric acid hydrochloride and dicyclohexylcarbodiimide are reacted in equimolar amounts according to Example 7 to produce the desired product.

Sources & evidence

ORD record
ord-59b7871643bb46bf88cc3f6a1d052946
Source dataset
uspto-grants-1977_05
Patent number
US04025630

Reaction notes

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