Dicyclohexylcarbodiimide → HCID 68127367, compound

Participants

Reaction Steps

3.21 g. (9.37 mmole) of 4,4-Dimethyl-9-hydroxy-7-(4-fluorophenyl-1-methyloctyl)-1,2,3,4-tetrahydrocyclopenta [c][1]benzopyran are combined with 1.82 g. (9.37 mmole) of γ-pyrrolidinobutyric acid hydrochloride and 2.06 g. (10.0 mmole) of dicyclohexylcarbodiimide in 150 ml. of methylene chloride and stirred at room temperature for 21/2 hours. The insoluble by-product of dicyclohexylurea is removed by filtration and the filtrate is evaporated to give a residue which crystallized upon standing. The material is triturated with ether and filtered. Recrystallization from benzene/ether gives the product as colorless crystals.

Provenance & Evidence