Dicyclohexylcarbodiimide → HCID 68121019, compound

Participants

Reaction Steps

2.5 g. (6.76 mmole) of 3-(4-fluorophenyl-1-methylbutyl)-1-hydroxy-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran is combined with 1.41 g. (6.76 mmole) of γ-piperidinobutyric acid hydrochloride and 1.48 g. (7.16 mmole) of dicyclohexylcarbodiimide in 125 ml. of methylene chloride and stirred at room temperature for 16 hours. The by-product of dicyclohexylurea is removed by filtration and the filtrate is evaporated to a residue. The residue is dissolved in ether and the small amount of solid which appears is removed by filtration. The ether is removed on a rotary evaporator and the gummy residue which remains is triturated several times with small quantities of hexane. The material is thoroughly dried to yield the product as a powder.

Provenance & Evidence