Triethylamine → HCID 2315017, compound

Participants

Reaction Conditions

Reaction Steps

83 g of 3-nitrobenzoyl chloride in 150 ml of acetonitrile are added dropwise to a solution of 105 g of 2-aminopropane-2-phosphonic acid diethyl ester and 45 g of triethylamine in 300 ml of acetonitrile at 0° C., with good stirring. After completion of the addition, the mixture is stirred for a further 3 hours at 0° C.; it is then filtered and the solvent is distilled off in vacuo. The residue is purified by extraction by shaking with ether and aqueous 2 normal sodium carbonate solution. 99 g of 2-(3'-nitrobenzamido)propane-2-phosphonic acid diethyl ester of melting point 95°-96° C. are obtained. This product is reduced with hydrogen as indicated in Example 2.

Provenance & Evidence