Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | Diethyl {[(pyridin-3-yl)amino]methylidene}propanedioate | HCID 2313092 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178469573 | HCID 178469573 | 75% |
Reaction Steps
A mixture of 265 g. of diphenyl and 735 g. of diphenyl ether is heated to 255° C., and then the above diethyl 2-([3-pyridylamino]methylene)-malonate is added all at once. The temperature of the mixture is maintained at 255° C. until ethanol is no longer evolved. The mixture is cooled to 25° C. and the precipitate is removed by filtration. It is washed liberally with hexane and dried. This affords 40.5 g. (75% yield) of ethyl 4-hydroxy-1,5-naphthyridine-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04026881 |
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| Source dataset | uspto-grants-1977_05 |
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| ORD ID | ord-08cf3a1022384660934400423e6b6757 |
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| Source note | uspto-grants-1977_05 |
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