HCID 12674740, compound → HCID 13533224, compound

Participants

Reaction Conditions

Reaction Steps

200 ml of sec-butylamine (III) was added to 10 g of 5-(α-bromobutyryl)-8-hydroxycarbostyril (IV) obtained as described in Examples 1 to 3, and the resulting mixture was heated at a temperature of 60° C for 20 hours followed by concentration to dryness. Crystals which formed upon addition of water were filtered, dissolved in 50 ml of ethanol, and the resulting solution was adjusted to a pH of 1 with concentrated hydrochloric acid. The precipitated crystals were filtered and recrystallized from methanol to obtain 8.3 g of 5-(α-sec-butylaminobutyryl)-8-hydroxycarbostyril (II) hydrochloride having a melting point of 212°-214° C (with coloring and decomposition).

Provenance & Evidence