Sec-Butylamine → HCID 13533224, compound

HRID 2398945Notes

Reaction equation

HRID 2398945 reaction equation
[CH:1]([NH2:5])([CH2:3][CH3:4])[CH3:2].Br[CH:7]([CH2:22][CH3:23])[C:8]([C:10]1[CH:19]=[CH:18][C:17]([OH:20])=[C:16]2[C:11]=1[CH:12]=[CH:13][C:14](=[O:21])[NH:15]2)=[O:9]>CO>[CH:1]([NH:5][CH:7]([CH2:22][CH3:23])[C:8]([C:10]1[CH:19]=[CH:18][C:17]([OH:20])=[C:16]2[C:11]=1[CH:12]=[CH:13][C:14](=[O:21])[NH:15]2)=[O:9])([CH2:3][CH3:4])[CH3:2]

Participants

4

Reactant 2

HCID 24874Sec-ButylamineHCID 12674740HCID 12674740, compound

Product 1

HCID 13533224HCID 13533224, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 ml of iso-propylamine (III) and 50 ml of methanol were added to 5 g of the 5-(α-bromobutyryl)-8-hydroxycarbostyril (IV) obtained in Examples 1 to 3. The resulting mixture was heated under refluxing for 6 hours followed by concentration to dryness. The reaction product was further worked up in the same manner as described in Example 1 to obtain 4.2 g of a methanol solvate of 5-(α-iso-propylaminobutyryl)-8-hydroxycarbostyril (II) having a melting point of 136°-137° C (with foaming and decomposition).

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureunder refluxing for 6 hours
  3. concentrationfollowed by concentration to dryness

Sources & evidence

ORD record
ord-4bf137f19573435387bbd42297e49ecb
Source dataset
uspto-grants-1977_05
Patent number
US04026897

Reaction notes

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