7-Amino-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid → 7-[[2-[4-(Chloromethyl)phenyl]-2-carboxyacetyl]amino]-3-[(2-methyl-1,3,4-thiadiazol-5-ylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

HRID 2398967ノート

反応式

HRID 2398967 の反応式
[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:13]([OH:15])=O)[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:16][C:17]1[S:18][C:19]([S:22][CH2:23][C:24]2[CH2:31][S:30][CH:29]3[N:26]([C:27](=[O:33])[CH:28]3[NH2:32])[C:25]=2[C:34]([OH:36])=[O:35])=[N:20][N:21]=1>>[Cl:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([C:10]([OH:12])=[O:11])[C:13]([NH:32][CH:28]2[C:27](=[O:33])[N:26]3[CH:29]2[S:30][CH2:31][C:24]([CH2:23][S:22][C:19]2[S:18][C:17]([CH3:16])=[N:21][N:20]=2)=[C:25]3[C:34]([OH:36])=[O:35])=[O:15])=[CH:7][CH:8]=1

参加物

3

反応物 2

HCID 31498227-Amino-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidHCID 22767749p-Chloromethylphenylmalonic acid

生成物 1

HCID 203258557-[[2-[4-(Chloromethyl)phenyl]-2-carboxyacetyl]amino]-3-[(2-methyl-1,3,4-thiadiazol-5-ylthio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

実験手順

When in the above procedure appropriate amounts of an acid derivative and acephalosporin derivative listed in the following Table X are substituted respectively for p-chloromethylphenylmalonic acid and 3-[(2-methyl-1,3,4-thiadiazol-5-ylthio)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid in the above procedure, the respective products listed in the following Table X are obtained.

後処理

  1. customare obtained

出典と根拠

ORDレコード
ord-a91c0f53e1834aeb958f18ce15f9bb77
出典データセット
uspto-grants-1977_05
特許番号
US04026887

反応ノート

読み込み中…