反应详情

To 0.05 g. of 1-(1-methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide is added 0.5 ml. of conc. sulfuric acid and the mixture is heated on a steam bath for 30 minutes. Ice is added to the reaction mixture and the solid is filtered. The filtrate is made basic with sodium hydroxide and cooled in an ice bath. The solid is filtered, washed with water and dried affording 17 mg. (37%) of 2-(2-amino-1,3,4-thiaziazol-5-yl)-1-methyl-5-nitroimidazole.

1. additionIce is added to the reaction mixture
2. filtrationthe solid is filtered
3. temperaturecooled in an ice bath
4. filtrationThe solid is filtered
5. washwashed with water
6. customdried
7. customaffording 17 mg