Triethylamine → HCID 86675792, compound

Participants

Reaction Steps

To a solution of 4-bromo-N-[2-(hydroxymethyl)-1-methyl-1H-indol-5-yl]benzamide (13.63 g) obtained in Example 20 in DMSO (136 mL) were added triethylamine (21.1 mL) and pyridine-sulfur trioxide complex (24.16 g), and the mixture was stirred at room temperature for 22 hr. The reaction mixture was poured into ice water (400 mL), and the precipitated crystals were collected by filtration, washed with water, and dried to give the title compound (12.49 g, yield 92%) as a pale-brown solid. The solid was used without purification for the next reaction.

Provenance & Evidence