1H-Indole-2-carboxylic acid, 1,3-dimethyl-5-nitro-, methyl ester → HCID 86675793, compound

Participants

Reaction Steps

To a solution of methyl 1,3-dimethyl-5-nitro-1H-indole-2-carboxylate (5.27 g) in THF (105 mL) was added 10% palladium carbon (50% water wet, 2.25 g), and the mixture was stirred at room temperature for 3 days under a hydrogen atmosphere (balloon). The insoluble material was filtered off and washed with methanol. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography [eluent; hexane:ethyl acetate=7:3-hexane:ethyl acetate=3:2 (volume ratio)] to give the title compound (4.63 g, yield 98%) as an orange solid.

Provenance & Evidence