Benzaldehyde → HCID 178521611, compound

Participants

Reaction Conditions

Reaction Steps

To methanol (1 kg) were added trans-4-aminocyclohexanol (200 g), benzaldehyde (553 g) and 10% palladium carbon (20 g), and the mixture was stirred under a hydrogen atmosphere at 60° C. for 24 hr. After cooling to room temperature, the catalyst was filtered off and washed with methanol (400 g). The filtrate and washings were added dropwise to water (2 kg) at 50° C. After cooling to room temperature, the precipitate was collected by filtration, washed with water:methanol=2:1 (volume ratio, 400 g) and dried under reduced pressure to give the title compound (472 g, yield 92%) as a white solid.

Provenance & Evidence