HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenyl Isocyanate → 1-(4-Chlorophenyl)-3-(1-pyrrolin-2-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-Amino-1-pyrroline hydrochloride | HCID 12778905 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(4-Chlorophenyl)-3-(1-pyrrolin-2-yl)urea | HCID 21406191 | — |
Reaction Steps
Following a procedure similar to that described in Example 1 but using 15.3 g. sodium in 1900 ml. dry acetone, 80 g. 2-amino-1-pyrroline hydrochloride, and 102 g. 4-chlorophenyl isocyanate in 500 ml. dry acetone, except that ice-bath cooling was applied during the addition of the isocyanate, there was obtained after recrystallization from ethyl acetate 66 g. 1-(4-chlorophenyl)-3-(1-pyrrolin-2-yl)urea; m.p. 147°-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04026938 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-48477b5ff5044161823ad52822e6d3eb |
| Source note | uspto-grants-1977_05 |