Water → HCID 178435602, compound

HRID 2399105Notes

Reaction equation

HRID 2399105 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1.[CH2:7]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[N:14][C:13]([C:19](Cl)=[O:20])=[CH:12]2)[CH3:8].O>N1C=CC=CC=1>[CH2:7]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[N:14][C:13]([C:19]([NH:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1)=[O:20])=[CH:12]2)[CH3:8]

Participants

5

Reactant 3

HCID 962WaterHCID 21432745HCID 21432745, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178435602HCID 178435602, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 5-amino-1,2,3,4-tetrazole (0.425 g.) in dry pyridine (10 ml.) was added to 6-ethylcinnolin-3-yl carbonyl chloride (1.1 g.). The resulting solution was kept at room temperature overnight, and water (50 ml.) and N-hydrochloric acid (50 ml.) were then added. The mixture was filtered, and the solid residue washed with water and crystallised from aqueous dimethylformamide to give 6-ethyl-N-(1,2,3,4-tetrazol-5-yl)cinnolin-3-yl carboxamide, m.p. over 250° C.

Workup

  1. filtrationThe mixture was filtered
  2. washthe solid residue washed with water
  3. customcrystallised from aqueous dimethylformamide

Sources & evidence

ORD record
ord-be88fc2094244b3aa14cc42ae2ee2572
Source dataset
uspto-grants-1977_05
Patent number
US04027023

Reaction notes

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