Diethylethanolamine → HCID 21432733, compound

Participants

Reaction Steps

A solution of 2-diethylaminoethanol (1.4 g.) in dry tetrahydrofuran (15 ml.) was added to a solution of 6-bromocinnolin-3-yl carbonyl chloride (1.07 g.) in dry tetrahydrofuran (15 ml.). The resulting solution was heated under reflux for 2 hours, and the solvent was then evaporated in vacuo. The solid residue was dissolved in water (50 ml.), the solution extracted with ethyl acetate (3× 100 ml.), and the combined extracts dried (MgSO4). The solution was evaporated to a small volume, petroleum ether (b.p. 60°-80° C.; 50 ml.) was added, the resulting mixture was filtered to give, as the solid residue, 2-diethylaminoethyl 6-bromocinnolin-3-yl carboxylate, m.p. 90°-93° C.

Provenance & Evidence