Acetic Anhydride → HCID 21432744, compound

HRID 2399110Notes

Reaction equation

HRID 2399110 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[N:7][C:6]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:5]2.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[N:7][C:6]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:5]2)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 21432715HCID 21432715, compound

Product 1

HCID 21432744HCID 21432744, compound

Conditions

Temperature
100 °C

Procedure

Ethyl 6-aminocinnolin-3-yl carboxylate (obtained as described below) was dissolved in acetic anhydride (25 ml.). The solution was heated at 100° C. for 16 hours and then allowed to cool to room temperature, and the resulting mixture was filtered to give, as solid residue, ethyl 6-acetylamino-cinnolin-3-yl carboxylate, m.p. 256°-258° C.

Workup

  1. temperatureto cool to room temperature
  2. filtrationthe resulting mixture was filtered

Sources & evidence

ORD record
ord-955a9d9cc2ce4a75970cfcc5211b1817
Source dataset
uspto-grants-1977_05
Patent number
US04027023

Reaction notes

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