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o-CRESYL GLYCIDYL ETHER → 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | o-CRESYL GLYCIDYL ETHER | HCID 16640 | — |
| 反応物 | 6-(2-Benzylamino-2,2-dimethylethoxy)-nicotinic acid amide | HCID 53961034 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol | HCID 21333233 | — |
反応手順
A solution of 12 g of 6-(2-benzylamino-2,2-dimethylethoxy)-nicotinic acid amide and 12 g of 1-(2-methylphenoxy)2,3-epoxy-propane in 150 ml of isopropanol is boiled for 28 hours under reflux. After working up analogously to Example 1(c), crude 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-1,1-dimethyl-ethyl]-amino]-3-(2-methyl-phenoxy)-2-propanol is obtained, which is used further without additional purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04027027 |
| 出典データセット | uspto-grants-1977_05 |
| ORD ID | ord-11cc49ab95dc4db1930c434929592b4a |
| 出典メモ | uspto-grants-1977_05 |