4-(N-Propionylaniline)piperidine → N-(2,6-dimethylphenoxyethyl)-4-(N'-phenyl-N'-propylamino)-piperidine

Participants

Role	Name	HCID	Charge
Reactant	4-(N-Propionylaniline)piperidine	HCID 259381	—
Reactant	2-(2-Bromoethoxy)-1,3-dimethylbenzene	HCID 2452208	—
Product	N-(2,6-dimethylphenoxyethyl)-4-(N'-phenyl-N'-propylamino)-piperidine	HCID 54259289	79.7%

Reaction Steps

Using the procedure described in Example I and starting from 12.7 g (2,6-dimethylphenoxyethyl) bromide and 12.8 g 4-(N'-phenyl-N'-propionylamino)-piperidine, 16.1 g of the title product are obtained melting at 82° after recrystallization from hexane. Mixing the compound with 4-(N'-phenyl-N'-propionylamino)-piperidine depresses the melting point.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04027028
Source dataset	uspto-grants-1977_05
ORD ID	ord-37cb28822f0a47079faff14e341d37ae
Source note	uspto-grants-1977_05