Ethanol → HCID 19386219, compound

Participants

Reaction Steps

2.0 g (8.4 mmol) of 2,5-dibromopyrimidine, 4.54 g (25.2 mmol) of 3-propoxybenzeneboronic acid, 5.34 g (50.4 mmol) of sodium carbonate and 0.10 g (0.9 mmol) of tetrakis(triphenylphosphine)palladium(0) are heated at 80° C. for 6 hours in 50 ml of toluene, 25 ml of ethanol and 25 ml of water. The reaction mixture is subsequently partitioned between water and ether, the organic phase is washed twice with sodium chloride solution, dried over sodium sulfate and evaporated, and the residue is purified by chromatography (silica gel/dichloromethane:ethyl acetate=98:2) and by recrystallization from n-hexane, giving 1.31 g of 2,5-bis(3-propoxyphenyl)pyrimidine. ##STR27## The compound has the phase sequence: X 81 I 31.6 X

Provenance & Evidence