2-Amino-4-methylpyridine → HCID 18348765, compound

Participants

Reaction Steps

To a solution of 3.3 ml (30 mmol) trichloromethanesulphenic acid chloride in 450 ml dichloromethane one adds dropwise at 0° C. a solution of 3.2 g (30 mmol) 2-amino-4-methylpyridine and 4.2 ml triethylamine in 25 ml. dichloromethane, stirs for 10 min and adds dropwise thereto a solution of 2.8 g (30 mmol) 4-aminopyridine and 12 ml triethylamine in 100 ml dichloromethane. After 3 h stirring at room temperature, one pours into water, extracts with ethyl acetate, dries the extract, evaporates and chromatographs on silica gel (elution agent ethyl acetate/isohexane 1:1), One isolates 1,2 g of title compound (17% of theory) of the m.p. 144°-145° C.

Provenance & Evidence