Trifluoroacetic acid → HCID 131719118, compound

Participants

Reaction Steps

Distilled TFA (4.60 ml, 59.6 mmol) was added dropwise to a solution of N-Boc-D-Pro-D-Phe-OBn (2.70 g, 5.96 mmol) in dry dichloromethane (5.0 ml), and the mixture was stirred at room temperature for 4 hours. TFA and solvent were then removed by evaporation under reduced pressure, and the resulting residue redissolved in chloroform. Water and solid potassium carbonate were added in amounts sufficient to achieve & pH of 10 in the resulting aqueous solution, and the aqueous layer was then extensively extracted with chloroform. The combined organic layers were dried over MgSO4 and concentrated to yield crude D-Pro-D-Phe-OBn as a yellow oil which was used without further purification.

Provenance & Evidence