2-n-Butyl-1-[(5-carbomethoxy-2-thienyl)methyl]imidazol-5-carboxaldehyde → (E)-3-[2-n-Butyl-1-{(5-carboxy-3-thienyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid

HRID 2399246Notes

Reaction equation

HRID 2399246 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:12][C:13]2[CH:17]=[C:16]([C:18]([O:20]C)=[O:19])[S:15][CH:14]=2)[C:7]([CH:10]=O)=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].C(C1N(C[C:34]2[S:35][C:36]([C:39](OC)=O)=[CH:37][CH:38]=2)C(C=O)=CN=1)CCC>>[CH2:1]([C:5]1[N:6]([CH2:12][C:13]2[CH:17]=[C:16]([C:18]([OH:20])=[O:19])[S:15][CH:14]=2)[C:7](/[CH:10]=[C:16](\[CH2:39][C:36]2[S:35][CH:34]=[CH:38][CH:37]=2)/[C:18]([OH:20])=[O:19])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 193873192-n-Butyl-1-[(5-carbomethoxy-2-thienyl)methyl]imidazol-5-carboxaldehydeHCID 193873262-n-Butyl-1-[(5-carbomethoxy-3-thienyl)methyl]imidazol-5-carboxaldehyde

Product 1

HCID 44210680(E)-3-[2-n-Butyl-1-{(5-carboxy-3-thienyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid

Procedure

The title compound was prepared following the procedures described in Example 1 (v-vi) using 2-n-butyl-1-[(5-carbomethoxy-3-thienyl)methyl]imidazol-5-carboxaldehyde (prepared by the methods described in Example 2 (i-iii)) in place of 2-n-butyl-1-[(5-carbomethoxy-2-thienyl)methyl]-imidazol-5-carboxaldehyde; mp 133°-135° C. (d).

Workup

  1. customprepared by the methods

Sources & evidence

ORD record
ord-423dc6b4232e466da1db656daf53ddc5
Source dataset
uspto-grants-1995_09
Patent number
US05447949

Reaction notes

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