Trifluoroacetic acid → HCID 19434251, compound

Participants

Reaction Steps

t-Butyl N-[6-(3,4,5-trimethoxybenzyloxy)imidazo[1,2-b]pyridazin-2-yl]carbamate (Example 13, 0.43 g, 1 mmol) was dissolved in dichloromethane (2 ml) and treated with trifluoroacetic acid (1 ml). After 2 h at ambient temperature the mixture was evaporated in vacuo to give a brown oil which was triturated with diethyl ether to give the title compound (0.25 g) as a cream solid, m.p. 150°-157°, NMR δH (DMSO) 8.0 (1H, JAB 8.8 Hz, 8H), 7.48 (1H, s, 3H), 7.16 (1H, JAB 8.8 Hz, 7H), 6.44 (2H, s, CH2), 4.5 (brs, NH3), 3.89 (6H, s, OMe) and 3.75 (3H, s, OMe).

Provenance & Evidence